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ba0001pp459 | Other diseases of bone and mineral metabolism | ECTS2013

Correlates of tissue mineral density of bone samples from total hip arthroplasty patients with type 2 diabetes: an ex vivo study

Pritchard Janet , Papaioannou Alexandra , Hurtig Mark , Giangregorio Lora , Atkinson Stephanie , Beattie Karen , Adachi J.D. , DeBeer Justin , Winemaker Mitchell , Avram Victoria , Schwarcz Henry

Introduction: Fracture risk is greater for adults with type 2 diabetes (T2D), despite normal or higher areal bone mineral density (aBMD) compared to controls. Tissue mineral density (TMD), measured by microCT, is more representative of actual mineral density than in vivo aBMD. The aim of this study was to determine whether TMD is greater in adults with T2D, and to investigate the correlates of TMD in adults with T2D.Methods: Using proximal femur...

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ba0003oc6.4 | Osteoporosis treatment and the effects of physical activity | ECTS2014

Long-term denosumab therapy further reduces the rate of non-vertebral fractures in women with persisting low hip BMD after 3 years

Ferrari S , Adachi JD , Lippuner K , Zapalowski C , Miller PD , Reginster J-Y , Torring O , Kendler DL , Daizadeh N , Wang A , O'Malley CD , Wagman RB , Libanati C , Lewiecki EM

Objective: Evidence for further reduction of nonvertebral fracture (NVFX) beyond 3 years of antiresorptive therapy is limited. Since long-term denosumab (DMAb) treatment is associated with continuous increases in BMD and sustained fracture reduction, we analyzed the influence of femoral neck (FN) BMD after 3 years on NVFX rates.Methods: Long-term subjects received 7 continuous years of DMAb; cross-over subjects received 3 years of placebo (FREEDOM) and 4...

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Bone Abstracts

Correlates of tissue mineral density of bone samples from total hip arthroplasty patients with type 2 diabetes: an ex vivo study

Long-term denosumab therapy further reduces the rate of non-vertebral fractures in women with persisting low hip BMD after 3 years

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